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Ameliorative Effect of The Essential Oil of Syzygium aromaticum in Wistars Rats Exposed to Aluminum Chloride

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Last updated: 03 Jan 2025

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Abstract

The objective of this study, on the one hand, is to evaluate the impact of aluminium intoxication, on the biochemical and hematological approaches of adult Wistar rats, on the other hand, to test the efficacy of Syzygium aromaticum essential oil (CEO) in restoring or not the harmful effects of the studied metal with a daily intraperitoneal injection of 0.1 ml CEO/kg. The extraction of the essential oil from S.aromaticum by hydro-distillation allowed us to obtain CEO with a yield of 10.18%. Chronic exposure to aluminum chloride at a concentration of 100mg/kg in rats decreased body and organ weights (Liver, Kidney) compared to controls. The intoxication also revealed a disruption of various biochemical parameters, including liver (TGO, TGP), and kidney (urea, creatinine) biochemical assays, Thus, the concentration of aluminium in the intoxicated group is high in the blood. Also, the results show a correction in the values of these parameters following the administration of CEO compared to those of exposed animals. CEO also corrected the shape of the affected blood cells after intoxication to aluminium. 

DOI

10.21608/eajbsc.2022.277234

Keywords

Syzygium aromaticum, aluminiumcloride, kidney, Liver, Blood

Authors

First Name

Djallal Eddine

Last Name

Adli

MiddleName

Houari

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

djillou2006@yahoo.fr

City

Algeria

Orcid

0000-0001-5495-2785

First Name

Kaddour

Last Name

Ziani

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

zianivet07@gmail.com

City

Algeria

Orcid

0000-0002-2453-6630

First Name

Dallal

Last Name

Kourat

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

-

City

Algeria

Orcid

-

First Name

Mostapha

Last Name

Brahmi

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria-Department of Biology, Faculty of Science and Technology, University of Relizane 48000, Algeria

Email

mostapha.brahmi20@gmail.com

City

Saida- Algerie

Orcid

0000-0003-4131-5802

First Name

Sendous

Last Name

Souidi

MiddleName

Adjila

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

-

City

-

Orcid

-

First Name

Asma

Last Name

Naar

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

-

City

Algeria

Orcid

-

First Name

Khaled

Last Name

Kahloula

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

bombixc2@yahoo.fr

City

-

Orcid

0000-0001-5278-305X

First Name

Miloud

Last Name

Slimani

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

Email

mslimani20@gmail.com

City

Algeria

Orcid

-

Volume

14

Article Issue

2

Related Issue

35452

Issue Date

2022-12-01

Receive Date

2022-10-15

Publish Date

2022-12-06

Page Start

403

Page End

413

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 14_Issue 2_Pages 403-413.pdf

PDF . 588.9kB

Link

https://eajbsc.journals.ekb.eg/article_277234.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=277234

Order

277,234

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Ameliorative Effect of The Essential Oil of Syzygium aromaticum in Wistars Rats Exposed to Aluminum Chloride

Details

Type

Article

Created At

22 Jan 2023