The current study included the biochemical evaluation of the effect of the COVID-19 vaccine (Sinopharm) among vaccinated individuals. The study included (90) blood samples of thirty people (each person has three samples) who received the Sinopharm vaccine, their ages ranged between (18-55) years and for both sexes, and the samples were divided into three groups; represented by a sample before the vaccine, a sample after receiving the first dose, and a sample after receiving the second dose of the vaccine. Samples were collected from the vaccine center in Al-Dhuluiya general hospital-Salah Al-Din who was vaccinated with the Sinopharm vaccine during the period from 1/11/2021 until 1/2/2022.
              Our study evaluated the level of some biochemical parameters, including- Lactate dehydrogenase-LDH activity, Troponin, D-dimer, Lipid profiles(Cholesterol, Triglycerides, Low-density lipoprotein cholesterol-LDL-C, High-density lipoprotein cholesterol-HDL-C), Total iron-TI, Transferrin, Ferritin, Total iron binding capacity-TIBC, Transferrin saturation, Malondialdhyde-MDA, Glutathione-GSH and peroxy nitrate.
             The results showed that LDH, Troponin, GSH and MDA levels were significantly elevated and the total iron, Transferrin, Total iron binding capacity-TIBC, and Transferrin saturation were significantly decreased after the first and second doses of the Sinopharm vaccine as compared with their levels before receiving doses vaccine. While the level of D-dimer, lipid profile, Ferritin and peroxy nitrate didn't show any significant difference after vaccination as compared with their levels before receiving the vaccine. So we can conclude that the vaccination with the Sinopharm COVID‐19 vaccine may affect the cardiac marker, iron state and oxidative stress state