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270217

The Therapeutic Effect of Cinnamomum cassia Essential Oil Against Mncl2-Induced Nephrotoxicity in Developing Wistar Rats

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Last updated: 03 Jan 2025

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Abstract

The present study aimed to evaluate the protective effect of Cinnamomum cassia essential oil on nephrotoxicity induced by manganese chloride (4.79mg/ml) in young Wistar rats during the development period. Wistar rat animals were exposed to manganese through maternal watering on a postnatal day (PND) 1 to (PND) 21. After weaning, the rats exposed to manganese received injections of Cinnamomum cassia essential oil (0.1 ml/kg) for 21 days. The concentration of manganese in the renal tissues was significantly increased compared to control rats. However, the levels of renal markers such as urea, uric acid, and creatinine were significantly increased in the blood after manganese chloride administration. Manganese-induced oxidative stress in renal tissue was indicated by decreased levels of superoxide dismutase, catalase, and glutathione peroxidase respectively. Histologically, the kidney showed several tissue alterations such as necrosis of the glomeruli and tubules. The administration of Cinnamomum cassia essential oil considerably attenuated the previous biochemical damage in serum and kidney tissue as well as histological and cellular modifications. In this study, it can be concluded that the Cinnamomum cassia essential oil showed a nephroprotective effect.

DOI

10.21608/eajbsc.2022.270217

Keywords

Manganese chloride, Nephrotoxicity, Cinnamomum cassia, Oxidative Stress, GC/MS

Authors

First Name

Mostapha

Last Name

Brahmi

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria -Department of Biology, Faculty of Science and Technology, University of Relizane 48000, Algeria

Email

mostapha.brahmi20@gmail.com

City

Saida- Algerie

Orcid

0000-0003-4131-5802

First Name

Djallal

Last Name

Adli

MiddleName

Eddine

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

Email

-

City

-

Orcid

-

First Name

Mokhtar

Last Name

Benrguieg

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

Email

mokhtar_benreguieg@yahoo.com

City

-

Orcid

-

First Name

Wafaa

Last Name

Arabi

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

Email

wafaaarabi@yahoo.fr

City

-

Orcid

-

First Name

Hmida

Last Name

Houari

MiddleName

-

Affiliation

Institue of Veterinary Sciences Ibn-Khaldoun University Tiaret 14000, Algeria.

Email

brahmi.mustapha@gmail.com

City

Algeria

Orcid

-

First Name

Mustapha

Last Name

Talatizi

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

Email

-

City

-

Orcid

-

First Name

Miloud

Last Name

Slimani

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

Email

mslimani20@gmail.com

City

-

Orcid

-

First Name

Khaled

Last Name

Kahloula

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

Email

bombixc2@yahoo.fr

City

-

Orcid

0000-0001-5278-305X

Volume

14

Article Issue

2

Related Issue

35452

Issue Date

2022-12-01

Receive Date

2022-10-07

Publish Date

2022-11-17

Page Start

257

Page End

266

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 14_Issue 2_Pages 257-266.pdf

PDF . 667.5kB

Link

https://eajbsc.journals.ekb.eg/article_270217.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=270217

Order

270,217

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

The Therapeutic Effect of Cinnamomum cassia Essential Oil Against Mncl2-Induced Nephrotoxicity in Developing Wistar Rats

Details

Type

Article

Created At

22 Jan 2023