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220567

Amelioration of Cisplatin-Induced Kidney and Liver Damage in Rabbits by Fresh Carrot (Daucus carota L) Juice.

Article

Last updated: 03 Jan 2025

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Abstract

The present study was carried out to investigate the protective effects of fresh carrot juice on Hepato renal injuries induced by a single intraperitoneal injection of cisplatin (CP) (5 mg/kg). The AST, ALT activities, and the levels of creatinine, urea were significantly (P < 0.05) increased in the serum of CP-treated rabbits (positive control) as compared to the normal rabbits (negative control). in contrast, Triglycerides and cholesterol concentrations were significantly decreased in the serum of CP-treated rabbits as compared to the normal rabbits. A dose of 5ml /kg body weight of fresh carrot juice was orally administered for 4 consecutive days before (CP) injection and 3 consecutive days after the (CP) injection reduced activities of AST, ALTand serum urea, serum creatinine levels which were altered by (CP), and succeeded in restoring of Triglycerides, cholesterol concentrations significantly to the normal range. On the other hand, histopathological Hepato renal tissue damage mediated by (CP) was greatly ameliorated by fresh carrot juice treatment. It was concluded that fresh carrot juice represents a potential therapeutic option to protect against (CP) Hepatorenal injuries commonly encountered in clinical practice.

DOI

10.21608/eajbsc.2022.220567

Keywords

carrot juice, daucus carota L, (CP), kidney and liver damage in rabbits

Authors

First Name

Tahani

Last Name

Omar

MiddleName

Y.

Affiliation

Department of Zoology, Faculty of Science, Sirte University, Sirte, Libya

Email

d.tahani@su.edu.ly

City

-

Orcid

-

First Name

Fahima

Last Name

Hammam

MiddleName

H.

Affiliation

Department of Zoology, Faculty of Science, Sirte University, Sirte, Libya

Email

-

City

-

Orcid

-

First Name

Intisar

Last Name

Abdallah

MiddleName

H.

Affiliation

Department of Zoology, Faculty of Science, Sirte University, Sirte, Libya

Email

-

City

-

Orcid

-

First Name

Warda

Last Name

Abdelhafiz

MiddleName

M.

Affiliation

Department of Histology, Faculty of Health Sciences, Sirte University, Sirte, Libya

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

29927

Issue Date

2022-06-01

Receive Date

2022-01-19

Publish Date

2022-06-01

Page Start

129

Page End

142

Print ISSN

2090-0767

Online ISSN

2090-083X

Link

https://eajbsc.journals.ekb.eg/article_220567.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=220567

Order

12

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Amelioration of Cisplatin-Induced Kidney and Liver Damage in Rabbits by Fresh Carrot (Daucus carota L) Juice.

Details

Type

Article

Created At

22 Jan 2023