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29079

In-Silico Study of Olive’s (Olea europaea L) Bioactive Compounds as Anti-Cancer Agents

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Last updated: 22 Jan 2023

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Abstract

        Recent studies suggest that Olives bioactive compounds are very important and mainly associated with cancer fight. They can suppress tumor growth through the direct interaction with several important proteins which are directly associated with tumor associated pathways such as P53, P16, P21, BCL2, BAX, MDM2, MMP2 and MMP9 proteins. The main aim of the present work is to perform a docking analysis of the Olives bioactive compounds with tumor-associated proteins. To do that, we first retrieved all the known structures of Olive bioactive compounds using different available online databases. Next, we analyzed these structures using Molegro Virtual Docker (MVD-2010, 4.2.0) software.  Further, we narrowed four important compounds (namely, Deacetoxyoleuropein aglycone, Hydroxytyrosol, Tyrosol and Erlotinib) of Olive bioactive compounds that showed very distinguished properties. The ADME properties of these four compounds were predicted based on Lipinski's rule of five. The active sites of the very widely known tumor-associated proteins (P53, P16, P21, BCL2, BAX, MDM2, MMP2 and MMP9) were explored using MVD software. Finally, the active sites of these proteins were docked with the above mentioned four compounds. Based on the docking study, it was concluded that Deacetoxyoleuropein Anglican showed strong inhibition with EGFR, VEGFR1 and VEGFR2. 

DOI

10.21608/eajbsc.2019.29079

Keywords

olive, Cancer, docking, MVD, Therapeutic

Authors

First Name

S.

Last Name

Shahida

MiddleName

M.A.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

2007.sma@gmail.com

City

-

Orcid

-

First Name

Mohammad

Last Name

Kuddusa

MiddleName

-

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Mohd

Last Name

Kausara

MiddleName

Adnan

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Basil

Last Name

Alshammari

MiddleName

E. K.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Musaabc

Last Name

Althaqafi

MiddleName

A. S.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Rakan

Last Name

Alshammari

MiddleName

E. K.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Sultan

Last Name

Alshmmary

MiddleName

N. H.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Hussain.

Last Name

Almudayni

MiddleName

K.A.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Khalid.

Last Name

Alshammary

MiddleName

M.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Sulaiman

Last Name

Alsamaan

MiddleName

S.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Abdalaziz

Last Name

alduhaim

MiddleName

S.

Affiliation

Department of Biochemistry, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Mohd

Last Name

Saleem

MiddleName

-

Affiliation

Department of Microbiology College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

First Name

Mohammad

Last Name

Qumani

MiddleName

Ahmed

Affiliation

Department of Pharmacology, College of Medicine, University of Hail, P.O. Box 2440, KSA

Email

-

City

-

Orcid

-

Volume

11

Article Issue

2

Related Issue

5098

Issue Date

2019-03-01

Receive Date

2019-02-15

Publish Date

2019-03-01

Page Start

21

Page End

29

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 11_Issue 2_Pages 21-29.pdf

PDF . 1.7MB

Link

https://eajbsc.journals.ekb.eg/article_29079.html

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https://eajbsc.journals.ekb.eg/service?article_code=29079

Order

2

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

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Article

Created At

22 Jan 2023