The potato plants (Solanum tuberosum L.) vs. valor were exposed to different levels of nitrogen fertilizer (60, 100, 140, 180 kg N/feddan (4200 m²)) and in-row plant spacing (12.5, 25 and 50 cm) for maximizing the yield production to match food security needs under climate change impacts on Delta region,  Egypt. The experiment was carried out during two growing seasons (2010/2011 and 2011/2012) in split plot design at El-Bossily Farm, Agricultural Research Center, El-Behira Governorate, Egypt. The vegetative growth characteristics and yield parameters were measured. The result of this study verified that increasing nitrogen level up to 180 kg N/feddan significantly increased the vegetative growth, total and marketable yields than the other N treatments. The in-row plant spacing 50 cm was significantly increased vegetative growth and yield (kg/plant), but the total yield (kg/m²) had different trend. The highest total yield /m² was obtained by 12.5 cm treatment. The interaction effect of 180 kg/feddan of N and 12.5cm in-row plant spacing were increased the total tuber yield (kg/m²) significantly. In contrary, the best marketable yield (tubers > 35 mm) /m² was obtained by 25 and 50 cm in-row plants.  This study was concluded that the best agronomic practices for potato production obtained by application 180 kg N/feddan of with in-row plant spacing 25 cm treatment. The economical consideration of the different treatments showed that the best total net income was obtained by 180 kg/feddan N with 50 cm in-row plant spacing.