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29013

Diverse origins of microbial L-asparaginases and their current miscellaneous applications

Article

Last updated: 22 Jan 2023

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Abstract

L-asparaginase, also known as amidohydrolase, catalyzes the breakdown of asparagine into aspartic acid and ammonia. Due to its ability to inhibit the biosynthesis of protein lymphoblasts, it is used to treat acute lymphoblastic leukemia (ALL). It also has other applications in the food industry by preventing the formation of acrylamide. Different organisms including bacteria, fungi, actinomycetes, and plants produce L-asparaginase. This review highlights different applications of L-asparaginase in the industrial fields, the major sources of L-asparaginase, its immunological reactions and production techniques through the solid state (SSF) and submerged (SmF) fermentation as well as optimization of the production process.

DOI

10.21608/aps.2019.20220

Keywords

L-asparaginase, Characterization, Optimization, Acute lymphoblastic leukemia

Authors

First Name

Nada

Last Name

Abdelrazek

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo, Egypt

Email

nada.anwar@fue.edu.eg

City

-

Orcid

-

First Name

Walid

Last Name

Elkhatib

MiddleName

Faisal

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Abbassia 11566, Cairo, Egypt

Email

walid-elkhatib@pharma.asu.edu.eg

City

-

Orcid

0000-0001-5815-3200

First Name

Marwa

Last Name

Raafat

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo, Egypt

Email

marwa.mahmoud@fue.edu.eg

City

-

Orcid

-

First Name

Mohammad

Last Name

Aboulwafa

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University

Email

maboulwafa@yahoo.com

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

2131

Issue Date

2019-01-01

Receive Date

2019-02-23

Publish Date

2019-06-01

Page Start

21

Page End

36

Print ISSN

2356-8380

Online ISSN

2356-8399

Article File

APS_Volume 3_Issue 1_Pages 21-36.pdf

PDF . 689.7kB

Link

https://aps.journals.ekb.eg/article_29013.html

Detail API

https://aps.journals.ekb.eg/service?article_code=29013

Order

3

Type

Review Article

Type Code

658

Publication Type

Journal

Publication Title

Archives of Pharmaceutical Sciences Ain Shams University

Publication Link

https://aps.journals.ekb.eg/

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Article

Created At

22 Jan 2023