The aim of this study was to determine the seasonal variations inphysicochemical and bacteriological parameters between inlet River Nile water and filtration water of Shoubra El-Khiema (SH) and Damietta (D) electric power plants. Total organic carbon (TOC) ranged between the highest values of 29.55-18 and the lowest values of 28.95-21 mg/l at (SH) and (D) River Nile water respectively. In filtration water, TOC ranged between 27.5-20- and 21.79 - 16 mg/l at (SH) and (D) filtration water respectively. Mean of electric conductivity values exceeded permissible limit 417 mg/l at (D) River Nile but it still within limits of filtration water at two plants. Sulphate mean values ranged between 39.5,43 and 19.7,26 mg/l at (SH) and (D) River Nile water respectively and it increased in filtration water to 77, 56 and 34, 41mg/l at (SH) and (D) respectively, than permissible limits at two plants. The bacteriological analyses recorded the highest values of TC, FC, FS and Pseudomonas sp. during summer at inlet River Nile of two plants, but decreased in filtration water at two plants.