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Synthesis and Characterization of Tb(III)-acetylacetone complex and its analytical application for hydrochlorothiazide determination in pharmaceutical preparation and biological

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Last updated: 24 Dec 2024

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Abstract

Tb(III)-Acetylacetone complex  was prepared and characterized by elemental analysis, UV/Vis, FTIR, 1H-NMR spectroscopy, mass spectroscopy, conductance and magnetism. The results indicated that the complex composition is [Tb(ACAC)2(NO3)(EtOH)2(H2O)2]. The prepared complex was used as optical sensor for hydrochlorothiazide determination in pharmaceutical tablets and biological fluids (serum and urine). The hydrochlorothiazide can remarkably enhance the luminescence intensity of the complex in DMSO at λex/em = 285/545 nm and pH 6.3. The dynamic ranges found for the determination of hydrochlorothiazide concentration are 3.6 x 10-9 to 4.0 x 10-6 mol L-1, and the limit of detection (LOD) and quantitation limit of detection (LOQ) are 1.3 ×10−9 and 4.2 x 10-9 mol L-1, respectively.
 

DOI

10.21608/jsrs.2015.18812

Keywords

Tb(ACAC), Optical Sensor, Luminescence Intensity, Enhancement, Hydrochlorothiazide

Authors

First Name

M.

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Chemistry, College of Women for Art, Science and Education, Ain Shams University, Cairo, Egypt

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-

Orcid

-

First Name

M.

Last Name

Attia

MiddleName

S.

Affiliation

Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

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-

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-

Orcid

-

First Name

M.

Last Name

Abd-Elzaher

MiddleName

M.

Affiliation

Inorganic Chemistry Department, National Research Centre, 33- El-Behouth St. (former EL Tahrir St.), Dokki, Giza, Egypt, P.O.12622

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Farag

MiddleName

B.

Affiliation

Department of Chemistry, Faculty of Science, Helwan University, Helwan, Egypt

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-

City

-

Orcid

-

First Name

A.

Last Name

Youssef

MiddleName

O.

Affiliation

Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Sheta

MiddleName

M.

Affiliation

Inorganic Chemistry Department, National Research Centre, 33- El-Behouth St. (former EL Tahrir St.), Dokki, Giza, Egypt, P.O.12622

Email

dr.sheta.nrc@gmail.com

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Orcid

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Volume

32

Article Issue

part 1

Related Issue

3825

Issue Date

2015-12-01

Receive Date

2018-11-12

Publish Date

2015-12-01

Page Start

291

Page End

307

Print ISSN

2356-8364

Online ISSN

2356-8372

Article File

JSRS_Volume 32_Issue part 1_Pages 291-307.pdf

PDF . 13.2MB

Link

https://jsrs.journals.ekb.eg/article_18812.html

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https://jsrs.journals.ekb.eg/service?article_code=18812

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Original Article

Type Code

656

Publication Type

Journal

Publication Title

Journal of Scientific Research in Science

Publication Link

https://jsrs.journals.ekb.eg/

MainTitle

Synthesis and Characterization of Tb(III)-acetylacetone complex and its analytical application for hydrochlorothiazide determination in pharmaceutical preparation and biological fluids

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Article

Created At

22 Jan 2023