Poly(vinyl alcohol)/ methyl cellulose (PVA/MC) blends, at different ratios were prepared into films by solution casting using, water as a common solvent, and gamma irradiated at various doses. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to study the thermal properties of gamma irradiated PVA/MC blends. It is expected that these methods would enable to understand the effect of gamma irradiation on the mechanism of thermal decomposition. The kinetic parameters such as energy of activation (E_a) and regression r² for the thermal decomposition were determined by three different methods. In the present work, the Coats-Redfern, Broido and Horowitz-Metzger methods were applied. The results indicated that the E_a and r² values of the gamma irradiated PVA/MC blends as determined by the three methods were comparable.