The objective of this study is to investigate the hypolipidemic effects of persimmon fruit on rats fed on high fat
diet. Three groups of male Wister rats were fed on: normal control (NC), high-fat (HF), and high fat supplemented
with whole dried persimmon (Pers/HF, 7%, wt/wt) diets. The results revealed that, the rat's body weight gain and
relative liver weight were significantly higher in the group fed on HF than the other two groups. The animals fed
on diets supplemented with persimmon had improved lipid profile as compared to high fat group. Furthermore, the
supplementation with persimmon induced a significant increase in levels of reduced glutathione and a reduction in
malondialdehyde level when compared to high fat group. In addition, the histopathological examination of the heart
and aorta in rats group fed on high fat showed severe histological changes as compared to supplemented persimmon
group, these results reflecting the protective effect of persimmon against atherosclerosis