Back ground: Nursing care for mechanically ventilated patients is an integral part of
changing the rate of ventilator associated infections in the intensive care units, also the time of
depending on mechanical ventilator. Aim: This study aimed to assess nursing performance toward
infection control measures for mechanically ventilated patients. Design: A descriptive explorative
design was utilized for the conduction of this study. Setting: this study was conducted in intensive
care units at emergency hospital affiliated to Ain Shams University. Study subject: A purposive
sample of 60 nurses who provide direct care for mechanically ventilated patients were included. Three tools
were used for data collection Tools: (I) - Self – administration questionnaire, (II) nurses' practice
observational checklist, (Ш) nurses' attitude questionnaire. Results: revealed that, 47% of studied
nurses had satisfactory knowledge, while 58.3% of them had unsatisfactory level of practices. Also,
65% of the studied nurses had positive attitude toward infection control measures for mechanically
ventilated patients. Recommendations: further researches are recommended to evaluate nurse's
performance regarding infection control measures for mechanically ventilated patients.