Background: The COVID-19 outbreak had a tremendous impact on the world of education. Aim: To assess maternity and medical surgical nursing students' preferences and experiences regarding traditional, blended and e-learning during COVID-19 pandemic in the Faculty of Nursing, Mansoura University. Tools: Three tools were used for data collection; the first tool was a student demographic questionnaire; the second and third tools were questionnaires to assess the students' preferences and experiences regarding the three methods of learning. Results: 60.8% of the studied students preferred blended learning. 87.8% of the studied students had previous negative experiences regarding traditional learning, 58.2% of them had a negative experience regarding e learning, and 67.1% of them had a positive experience regarding blended learning. Conclusion: Concerning the students' preferences, just over three-fifths of the studied students preferred blended learning, around one-third preferred traditional learning and a minority of them preferred e-learning. Regarding the students' experiences, the majority of the studied students had a negative experience regarding traditional learning, around three-fifths of them had a negative experience regarding e learning and more than two-thirds of them had a positive experience regarding blended learning. In general, the studied students preferred and had a positive experience regarding blended learning. Recommendation: Continuing following blended learning in the higher education faculties and institutions according to students' preferences and positive experiences in learning and not being dependent on traditional learning or e-learning delivered separately.