Background: Quarantine is used worldwide to interfere with COVID-19 transmission. It had a negative effect on the scholastic performance and behavior of regular students. Objective: The study strived to investigate such parameters on gifted students. Methods: A self-administered questionnaire was distributed to the parents of 378 gifted students all over Saudi Arabia, through their schools. These students were represented by Mawhiba Foundation, Saudi Arabia. Results: The findings showed that 70.4 % of the gifted students had an increase in their academic achievement at the end of the second semester. Moreover, 50.3% of the participants had experienced major behavioral changes during quarantine. Also, 56.9% of students suffered from annoying dreams and difficult sleeping. More than half of the participants faced distant learning problems. The correlation analysis indicated a significant and positive correlation between gifted students' academic achievement, entertainment hours, and parenteral help, while it was significant and negative between the academic achievement and the number of sleeping hours. Conclusion: Quarantine had a great psychological burden on the parents of the gifted students that was reflected on their behavior. However, most students faced different problems during the online distance learning, but their academic achievement had increased that might explain their unique mental ability.