Background: Breast cancer represents 10% of all cancers diagnosed worldwide annually and constitute 22% of all new cancers in women. The burden of breast cancer has increased steadily, almost doubling, in terms of estimated new cases annually over a 20-year span. Objective: This study was aimed to evaluate the outcome on oncological standard and patient satisfaction on the aesthetic side with skin-sparing mastectomy and immediate breast reconstruction for patients with early breast cancer. Patients and methods: this study included 80 female patients with breast cancer, 60 cases were operated upon at National Cancer Institute (NCI), Cairo University, 20 cases were operated upon at Oncosurgery Unit, Aswan University Hospitals, between 2015 and 2019. Results: In the current study, all patients were closely followed up to detect any signs of local recurrence (LR). The duration of postoperative follow up ranged from 24 to 48 months with a mean of 31.55 months. Only 1 patient (1.2 %) showed signs of local recurrence after 1 year of surgery. This condition was not associated with any sign of regional or systemic recurrence. This low incidence of local recurrence may be attributed to the early stage of the disease at the time of surgical intervention, the mastectomy procedure itself and the justified administration of neoadjuvant and adjuvant therapy to the studied patients. However, a relatively short period of follow up might be a drawback of obtaining a solid conclusion. Conclusions: It could be concluded that skin sparing mastectomy and Immediate breast reconstruction is a technically feasible and oncologically safe procedure. Accepted cosmetic result was attained in most of patients.