Background: Bone profile parameters are affected by decreased estimated GFR within chronic kidney disease  stage 3. We aimed to investigate if  bone  profile  parameters  response   to vitamin  D3 supplementation , within  this  stage , became  affected  by  the  presence or absence of  diabetic  state.  Materials and methods: 30 patients having chronic kidney disease (stage 3)   were  enrolled  in  the  study. 19 patients constituted non – diabetic group I and 11 patients constituted  diabetic  group II . All of them   have received vitamin D3  1000 IU  daily  for  3  months . For all patients the following measurements were  performed  before  and  after  vitamin  D3  use :CBC , ESR1 & ESR2 , blood urea , serum  creatinine , estimated  GFR , complete  urine  analysis  , serum Na , protein / creatinine  ratio , serum calcium , serum phosphorus , calcium – phosphorus  product , serum  albumin  , serum  alkaline phosphatase  ,  and  intact  serum  parathyroid  hormone. Results: Serum calcium levels have increased, while   intact parathyroid  hormone   has  decreased  within  both  groups  , with  a  more  obvious  response  within  the  diabetic  group . Serum alkaline phosphatase , serum  phosphorus , and  calcium – phosphorus  product   did  not  show  any significant   change, they were   within  their  level  after  vitamin  d3  use .ESR 1 and  ESR 2 levels were  higher  from the  start of  the study    within the  diabetic  group. Their mean  level  values   have significantly   decreased   in  a  highly  significant  way  within  this  group . Kidney function parameters  and  proteinuria  have  been  deteriorated  within  the  two  groups , being  worse  within  the  diabetic  group . Conclusion: Vitamin D3 use within stage 3 chronic renal disease patients  is  effective  for  patients  support  against  bone  mineral  disturbances  occurring  within  this  disease    .