Aflatoxicosis represents one of the serious diseases of poultry. The objective of the present study was to evaluate the efficacy of curcumin (CM), silymarin (Sil) and Nutritox in reducing the toxic effects of aflatoxin in white pekin ducklings. One hundred ninety two one day old white pekin ducklings were equally divided randomly into 8 equal groups, which include the following:  The control group was fed commercial broiler feed that were tested to be free from aflatoxin, while another expermintal groups, namely  2, 3, 4, 5, 6, 7 and 8 were containing, respectively, G2) basal diet (BD) + 700 ppb AF (aflatoxin); G3)  BD + 700 ppb AF +10mg/kg feed CM (curcumin); G4) BD + 700 ppb AF + 500mg/kg of BW Sil (Silymarin); G5) BD + 700 ppb AF + 1gm/kg feed Nutritox; G6) BD + 10mg/kg feed of CM; G7) BD + 500mg/kg of B.W Sil; G8) BD + 1gm/kg feed Nutritox during study (1-21days). Results showed that, the addition of 1gm/kg feed Nutritox ameliorated to some extend the adverse effects of AF diet and improved growth performance. The addition of CM or Sil or Nutritox ameliorated the adverse effects of AF on some serum chemistry parameters [total protein, Creatinin, Aspartate aminotransferase during cetrain periods of our experiments (AST), alanin aminotransferase (ALT) and Alkaline phosphatase (ALP)]. Results revealed that the administration of CM, Sil and Nutritox in diet prevent or reduce some adverse effects of aflatoxin in ducks fed aflatoxin-conatminated diets during different periods of our experiments. Our study concluded that Nutritox can provide protection against aflatoxin more than curcumin and silymarin.