Hyperlipidemia is one of the most public health problems in the modern era that increase the risk of several comorbidities such as cardiovascular disease and cancer. So, this study was investigated the effect of pomegranate seeds and wheat germ oils as protective agents against hyperlipidemia in rats. Thirty six male albino rats (Sprague Dawley strain) weight 120±10g. were investigated. Rats were divided into six equal groups, the first group kept as a control negative group and was fed on basal diet. While , the second group was fed high fat diet for 4 weeks as a positive control group .The third and fourth groups were fed on high fat diet and given administration of pomegranate seed oil (0.4 and 0.8 ml/kg. B. Wt.) orally for 4 weeks as a protective agent, respectively. The fifth and sixth groups were fed on high fat diet and given administration of wheat germ oil (1 and 1.5 /kg. B. Wt.) orally for 4 weeks as a protective agent, respectively. At the end of the experiment period (4 weeks), the feed intake (FI), body weight gain (gm.), feed efficiency ratio (FER) and relative liver weight were calculated. Serum liver enzymes (ALT, AST and Alp), total cholesterol, triglycerides, HDLc and LDLc and histopathological changes of heart were examined. Total antioxidant and total polyphenols were performed in pomegranate seeds and wheat germ oils . The obtained results concluded that using ( pomegranate seeds and wheat germ oils) improved all above biological and biochemical parameters. The best results found by using high doses of pomegranate seeds and wheat germ oils .According to the results, pomegranate seeds and wheat germ oils could be used for improving lipid profile and liver functions in hyperlipidemic rats.