Red radish sprouts (RRS) (Raphanus sativus) are rich sources of health-promoting phytochemicals more than in its seeds. The present study aimed to evaluate the protection efficiency of red radish sprouts as hypocholesterolemic and antiobesity agents in adult females. Forty-five females with body mass index (BMI) ≥28 and aged between 25 and 40 years were randomly divided into three groups each one containing 15 females; RRS group and the controls. G1 (the first control) consumed their usual diet, while the second control group includes participants who were subjected to a low-calorie diet individually. The third group includes participants who were subjected to a low-calorie diet with RRS (100 g per day). Participants were initially submitted to anthropometric measurements (weight, body fat %, height, waist circumference, and mid-upper arm circumference ), and blood samples for analysis of serum glucose, lipid profile (total cholesterol, HDL-c, LDL-c, and triglycerides) AST, ALT and TSH levels, total protein, and serum albumin. Then the groups started the intervention protocol lasting 8 weeks. After an 8-week follow-up period, the study results showed that the consumption of RRS significantly (P ≤ 0.05) suppressed the elevations in body weight (~12 %), serum cholesterol (~27.5 % reduction), serum triglycerides (~33 % reduction), AST and ALT (~35 and 21 % reduction respectively) and glucose (~7 % reduction). This work reveals, for the first time, the hypolipidemic and antiobesity potential role of RRS in adult females.