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160361

Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pharmacognosy

Abstract

The aim of the present study is the evaluation of the in-vitro cytotoxicity and antileishmanial activities of a methanolic extract and its different fractions of the soft coral Sarcophyton spongiosum collected from the Egyptian Red Sea against three cancer cell lines, A549, HepG2, and MCF-7, and a protozoan, Leishmania Major, by the MTT assay protocol. The dichloromethane fraction exhibited significant anti-Leishmania major (IC50 28.1 ± 1.2 µg/mL) and cytotoxic activities against MCF-7 cell line IC50 (31.5 ± 1.1 µg/mL). The ethyl acetate fraction showed promising cytotoxicity against A549 and HepG2 cell lines (IC50 13.4 ± 1.2 and 11.6 ± 1.9 µg/mL, respectively). A preliminary chemical screening of the total methanolic extract indicated of the presence of sterols and diterpenes.

DOI

10.21608/jabps.2021.62964.1120

Keywords

Soft corals, Sarcophyton spongiosum, Cytotoxicity, anti-Leishmania, MTT assay

Authors

First Name

Mostafa

Last Name

Fouad

MiddleName

A.

Affiliation

Pharmacognosy Department, faculty of Pharmacy, Minia University, Minia 61519, Egypt

Email

m_fouad2000@yahoo.com

City

-

Orcid

0000-0002-3909-3537

First Name

sabry

Last Name

Zidan

MiddleName

-

Affiliation

Departement of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt

Email

desabry2010@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Orabi

MiddleName

A. A.

Affiliation

Departement of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt

Email

mohamedorabi@azhar.edu.eg

City

-

Orcid

-

First Name

Reda

Last Name

Abdelhamid

MiddleName

A.

Affiliation

Departement of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt

Email

reda.ahmed@azhar.edu.eg

City

-

Orcid

-

First Name

Abdallah

Last Name

Allian

MiddleName

-

Affiliation

Departement of Zoolgy, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, Egypt

Email

aliancoral86@azhar.edu.eg

City

-

Orcid

-

First Name

katsuyoshi

Last Name

matsunmai

MiddleName

-

Affiliation

Departement of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan

Email

matunami@hiroshima-u.ac.jp

City

-

Orcid

-

Volume

4

Article Issue

2

Related Issue

23463

Issue Date

2021-04-01

Receive Date

2021-02-17

Publish Date

2021-04-01

Page Start

107

Page End

110

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 4_Issue 2_Pages 107-110.pdf

PDF . 379.0kB

Link

https://jabps.journals.ekb.eg/article_160361.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=160361

Order

7

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Cytotoxicity and anti-leishmanial activity of the Red Sea soft coral Sarcophyton spongiosum

Details

Type

Article

Created At

22 Jan 2023