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MICROBIAL TRANSFORMATION OF 2,5 DIHYDROXYCINNAMIC ACID BY ASPERGILLUS NIGER AND RHIZOPUS ORYZAE

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Last updated: 03 Jan 2025

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Abstract

2,5-dihydroxy cinnamic acid (1), when fermented with fungal culture, Rhizopus oryzae RCMB 014002 gave mainly two metabolites; 2,5-dihydroxy cinnamoyl alcohol (Cin-RM-1) and 2-Hydroxy-4,5-dimethoxy cinnamoyl alcohol (Cin-RM-2). Aspergillus niger RCMB002007, however, transformed 2,5-dihydroxy cinnamic acid (1), into a major metabolite;2-hydroxy-5-methoxy cinnamic acid (Cin-AM-3). The structures of the metabolic products were elucidated by means of spectroscopic data. The significance of the metabolites as antioxidants using DPPH radical scavenging assay and lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat tissue homogenates in relation to their structure was discussed.

DOI

10.21608/ajps.2014.6960

Keywords

Microbial transformation, 2, 5 dihydroxy-cinnamic acid, Aspergillus niger, Rhizopus oryzae, Antioxidant activities

Authors

First Name

Mohammed

Last Name

Hosny

MiddleName

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Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

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Volume

49

Article Issue

1

Related Issue

1336

Issue Date

2014-03-01

Receive Date

2018-05-13

Publish Date

2014-03-01

Page Start

104

Page End

116

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 49_Issue 1_Pages 104-116.pdf

PDF . 606.8kB

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https://ajps.journals.ekb.eg/article_6960.html

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https://ajps.journals.ekb.eg/service?article_code=6960

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7

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Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

MICROBIAL TRANSFORMATION OF 2,5 DIHYDROXYCINNAMIC ACID BY ASPERGILLUS NIGER AND RHIZOPUS ORYZAE

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Article

Created At

22 Jan 2023