Black berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions including but not limited to cardiovascular disorders, advancing age-induced oxidative stress, also improves neuronal and cognitive brain functions. The aim of the present study was to determine biological effects of daily intake of blackberry juice (BBJ) in the presence of aluminum chloride (AlCl₃). Male Albino mice (n: 32) averaging 18 to 23 g body weights were classified into four equal groups of eight mice each. Dietary treatments groups were; 1) a control, 2) given AlCl₃ (75 mg/kg BW) intraperitoneally (ip), 3) given BBJ (1.6 g/kg BW) orally and 4) treated with AlCl₃ and BBJ at the same mentioned doses. Mice were daily administered their respective doses for six weeks. BBJ increased RBCs than the control group and also reduced glucose, creatinine, uric acid and bilirubin than AlCl₃ group. Treatment with BBJ alone reduced cholesterol, triglyceride, LDL and VLDL levels than AlCl₃ group or AlCl₃ + BBJ group, respectively. Histological examinations showed that AlCl₃ group showed a moderate to marked neurodegeneration change in the form of necrosis and vacuolation with an increase in neurofibrillary tangle, while AlCl₃ and BBJ showed improvement in brain architecture with mild necrosis and neurofibrillary tangle .On the other hand, BBJ reversed normal brain tissue contains glial and pyramidal cells showing no necrosis or vacuolation. The granular cell showed no neurodegeneration change as the control group. These results revealed that a daily intake of BBJ was able to improve the lipid profile, reduce the high levels of total cholesterol, LDL and triglycerides, resulting in playing an important role in the prevention of cardiac damage. BBJ intake during exposure to aluminum could be recommended for reverting back brain oxidative stress and neurological disorders.