The present work aimed to evaluate the antiviral and anticancer potentials of reusable orange albedo extract (OAlbE) and grape seed extract (GSE) wastes. Results revealed that the IC₅₀ values of OAlb M/E and GSE M/E extracts with MCF-7 cell lines were 184439, 48108, 344,11.68 µgm / ml and was 6016 µgm / ml for SGSE 24 hrs post treatment respectively while the IC₅₀ values of the extracts with Caco-2 cell lines were 23708, 14107, 1158,15607 µgm / ml and was 430 µgm / ml for SGSE 24 hrs post treatment, respectively . The SGSE was of a higher potential toxicity to experimental extracted one. Antiviral activity of E/M OAlbE and GSE showed the same antiviral potential against  RVFV recording 0.51 log ₍₁₀₎ / 0.1 ml  ; (6.58%) and 1 log ₍₁₀₎ / 0.1 ml   (12.9%)  respectively. While the antiviral potential against HAV revealed that OAlbE/M and GSME showed low potential against HAV recording 0.26 log ₍₁₀₎ /0.1 ml. On the contrary both O-AlbE and GSME showed no antiviral potentials compared with Standard IFN (5 IU/ml) recorded a depletion of viral infectivity titers recording 3.25 log ₍₁₀₎ / 0.1 ml (41.93%) and 3 log ₍₁₀₎ /0.1 ml (40%) for RVFV and HAV respectively. Also, anticancer potentials was proved as there was a remarkable BCL-2 , P53 and Bax genes expression compared with control respectively.  It can be concluded that both E/M OAlb and GSE are promising antiviral and anticancer agents. More intensified investigations must be conducted to maximize the biological potentials   of both extracts. A higher level of characterization of extract contents must be achieved and evaluated for targeting the most promising fraction has both bioactivities considered