Purpose: To evaluate the efficacy of resin infiltration in treatment of young permanent teeth and to evaluate dental anxiety related to resin infiltration procedure and the time required.  Material and methods: 22 Egyptian children ranging from 6-14 years of age were selected with at least 2 smooth surface white lesions (WSL), one on each side using split mouth design. Lesions were assigned in a random way into 2 groups; Group I, Group II. Group I: resin infiltration, Group II: fluoride varnish. Radiographic and Photographic records were taken before treatment, immediately after treatment and 12 months plus assessing the marginal adaptation and discoloration. A facial image scale (FIS) was recorded. The outcome data were recorded, tabulated, coded to be statistically analyzed. Results: by radiographic evaluation immediately after treatment and through the study period the difference was statistically significant in the mean of DSR and RD between groups in favor of group I. By the descriptive analysis the difference of mean of change in both marginal adaptation and discoloration was not a statistically significant. While group I, show increase in mean of marginal adaptation but did not reach to significance level. But within group II, the mean of discoloration has shown statistically significantly difference. Dental anxiety was low in both groups with no statistically significantly difference. Conclusion: Infiltration concept was bridging the gap between “wait and see"; it is a promising micro-invasive approach.