Purpose: The objective of this study was to prepare an experimental dental composite resin core material loaded with prepared nanotitanium dioxide fillers and to evaluate the compressive strength of the experimentally prepared composite materials Materials and methods: prepared nanotitanium dioxidefillers, commercial nanosilica were used as a filler added to the experimentally prepared resin matrix and commercially available resin core material Nexcomp was used as a control. Preparation and characterization of a nanotitanium dioxide fillers through the following techniques: X-ray diffraction (XRD) analysis, Fourier transform infrared (FTIR) spectroscopy analysis, Scanning electron microscopic (SEM) analysis, EDX analysis,Transmission electron microscopy (TEM) analysis, and Thermal gravimetric analysis (TGA). then added to the prepared resin matrix BisGMA: TEDGMA(70%:30%) mixed with 0.5 wt% camphorquinone and 0.5 wt% ethyldimethyl amine. Testing of compressive strength was done. Results: revealed that there was no significant difference in the compressive strength between the experimental and Nexcomp core composite. Conclusions: It was concluded that experimental core composite showed a comparable mechanical properties to a commercial nanocomposite core resin regarding Compressive strength