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245225

Systematic Review and Meta-analysis of Zinc Supplementation and Stunting in Children under 5 years of age

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Maternal and Infant Nutrition

Abstract

The prevalence of zinc deficiency is 28 % of stunted Egyptian children. Therefore, this study was done to determine whether zinc supplementation strategy is feasible and effective for reducing growth retardation at national level. We conducted literature searches of electronic databases of the international standard randomized control trial number register that reported on the effect of zinc supplementation in infants or children below 5 years old. The findings were pooled using random effects meta-analysis; we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines during all stages of implementation, analysis, and reporting of these meta-analyses after testing of homogeneity. The final fifty four randomized controlled trials included in the meta-analysis showed the zinc supplementation had a greater effect on height and Height for age z-score in children compared with infants (P-interaction = 0.002 and 0.06, respectively). Among children aged ≥2 years, zinc increased height (N = 7 trials; WMD = 1.37 cm, 95%CI: 0.50–2.25) and, height for age z-score (N = 6 trials; WMD = 0.12, 95%CI: 0.05–0.19). Zinc supplementation significantly increased  height (N = 40 trials, WMD = 0.23 cm, 95%CI: 0.09–0.38; I2 = 66.9%) showed 28 of 40 studies (70%) had a positive effect of zinc supplementation among children aged < 5 years old on height in randomized controlled trials and, ten of them were statistically significant. Oral zinc supplementation among children aged from 2-5 years is recommended. However, further studies are needed

DOI

10.21608/bnni.2022.245225

Keywords

Stunting, infants, zinc supplementation, Height, children

Authors

First Name

Gihan

Last Name

Ahmad

MiddleName

Fouad

Affiliation

National Nutrition Institute- Cairo - Egypt

Email

-

City

Cairo

Orcid

-

First Name

Hanaa

Last Name

Ahmed

MiddleName

Sabry

Affiliation

Harvard Medical School Associate - Cairo- Egypt

Email

-

City

Cairo

Orcid

-

First Name

Enas

Last Name

Abbas

MiddleName

Sayed

Affiliation

Clinical Nutrition Department- National Nutrition Institute- Cairo - Egypt

Email

enas.sayed09@yahoo.com

City

Cairo

Orcid

-

Volume

59

Article Issue

1

Related Issue

35047

Issue Date

2022-06-01

Receive Date

2022-06-21

Publish Date

2022-06-01

Page Start

55

Page End

83

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 59_Issue 1_Pages 55-83.pdf

PDF . 2.1MB

Link

https://bnni.journals.ekb.eg/article_245225.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=245225

Order

245,225

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Systematic Review and Meta-analysis of Zinc Supplementation and Stunting in Children under 5 years of age

Details

Type

Article

Created At

22 Jan 2023