Beta
ManageSearchChatDiscover
231583

Biological and biochemical studies on the effect of different quercetin levels of toxic dietary acrylamide on rats

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Bioavailability of nutrients and metabolism

Abstract

Quercetin is a flavonoid that is present in many different foods. Quercetin has several health advantages, including improved non-communicable diseases. Acrylamide can be produced by the Maillard reaction of amino acid and reducing sugars. As a result, the effects of varying amounts of quercetin on the harmful effect of toxic dietary acrylamide were studied. Forty male albino rats (Sprague Dawley) have been split into five groups (eight rats each), and every group was fed an experimental diet for 28 days. The negative control group was given only a baseline diet, whereas the positive control group was intake both a baseline diet and 4 μg/kg body weight (BW) of acrylamide each day. Groups 2, 3, and 4 were fed a basal diet comprising of 4 μg kg/BW each day of acrylamide with 50, 100, and 200 mg of quercetin powder/kg BW/day. The results showed that treatment with acrylamide alone significantly, (p≤ 0.05) decreased the relative body weight; feed efficiency ratio (FER), feed intake and increased tested relative organs weight. In addition, the results revealed that the positive control group had an inhibitory impact on butyrylcholinesterase, lactate dehydrogenase activity, the immunity index, an increase in malondialdehyde activities, and the harmful effect on the histological structure of the rats' liver and brain. Whereas treatment with different levels of quercetin significantly improved all tested parameters especially, at a high dose of quercetin (200 mg). For that, adding quercetin or their dietary sources in fried meals may be significant to reduce hazardous acrylamide.

DOI

10.21608/bnni.2021.231583

Keywords

Quercetin, acrylamide, Liver, Brain, immunity

Authors

First Name

Hoda

Last Name

El Gezery

MiddleName

M.

Affiliation

Department of Field Studies and Survey- National Nutrition Institute, Cairo, Egypt

Email

hodamasoud17@yahoo.com

City

Cairo

Orcid

-

First Name

Hanady

Last Name

Sheha

MiddleName

G.

Affiliation

Department of Clinical Nutrition- National Nutrition Institute, Cairo, Egypt

Email

-

City

Cairo

Orcid

-

Volume

58

Article Issue

2

Related Issue

32889

Issue Date

2021-12-01

Receive Date

2022-04-18

Publish Date

2021-12-01

Page Start

68

Page End

90

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 58_Issue 2_Pages 68-90.pdf

PDF . 1.5MB

Link

https://bnni.journals.ekb.eg/article_231583.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=231583

Order

231,583

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Biological and biochemical studies on the effect of different quercetin levels of toxic dietary acrylamide on rats

Details

Type

Article

Created At

22 Jan 2023