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169343

The effect of dried bottle gourd and pumpkin as hepatoprotective agent from acrylamide toxicity in experimental rats

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Bioavailability of nutrients and metabolism

Abstract

Acrylamide (ACR) is found in foods containing carbohydrates and proteins, where it is formed during the thermal processing. It is classified as neurotoxic and probably carcinogenic to humans. The present study investigated the effect of dried pumpkin and bottle gourd versus acrylamide induced oxidative stress and hepatotoxicity in male albino rats. The rats were divided into equal six groups. The first group (6 rats) were fed on basal diet and served as negative control. The all other groups were injected intraperitoneal (i.p.) with acrylamide (50 mg/kg body weight) for 28 days. The second group fed on basal diet and served as a positive control group. The third and fourth groups fed on basal diet supplemented with bottle gourd fruits powder (5%) and (10%). The fifth and sixth groups fed on basal diet added with pumpkin fruits powder (5%) and (10%). The chemical composition and phenolic compounds of both fruits were done. At the end of the experiment biological data were calculated, blood samples were taken to biochemical analysis. In addition, liver tissues were analyzed for antioxidant markers, malondialdehyde (MDA), as well as histological examination was done.  The results revealed that acrylamide group increased liver weight, liver functions, serum lipid profile, liver MDA and NO, decreased in serum HDL-C, Liver GPX, SOD and CAT. All treated groups with two fruits showed improvement previously parameters compared with positive control group. In conclusion, the consumption of pumpkin and bottle gourd fruits powder can lower the side effects of acrylamide toxicant.

DOI

10.21608/bnni.2020.169343

Keywords

acrylamide, Bottle gourd, Pumpkin, Hepatotoxicity

Authors

First Name

Mona

Last Name

Serag

MiddleName

Ebrahim

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Egypt.

Email

-

City

Tanta

Orcid

-

First Name

Eman

Last Name

Abd-Elhady

MiddleName

E

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Egypt.

Email

-

City

Tanta

Orcid

-

First Name

Amira

Last Name

Elmoslemany

MiddleName

morsey

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Egypt.

Email

amiraelmoslemany@azhar.edu.eg

City

Tanta

Orcid

-

Volume

55

Article Issue

1

Related Issue

23814

Issue Date

2020-06-01

Receive Date

2020-05-03

Publish Date

2020-06-01

Page Start

73

Page End

107

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 55_Issue 1_Pages 73-107.pdf

PDF . 1.2MB

Link

https://bnni.journals.ekb.eg/article_169343.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=169343

Order

3

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023