Medicinal plants have been used at the suitable levels in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The present study was investigated the effects of Rhubarb, and Hibiscus on healthy status of rats. Twenty one male albino rats Sprague – Dawley were divided into (3) groups (7) rats in each group. The first group was control which fed on basal diet only as a control group. The second group was fed on basal diet containing 10% from rhubarb and the third group fed on basal diet containing 10% from hibiscus. Liver functions was assessed by estimation of plasma concentration of enzymes activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid fraction (total cholesterol and triglyceride) and cholesterol fractions (HDL-c, LDL-c, VLDL-c) and determined total immunoglobulin (IgG, IgM, IgE and IgA). Result showed that the hibiscus has a good effect on immunoglobulin test and showed increased in the liver enzymes, cholesterol fractions while decrease the level of HDL-c. Conclusion: This study concluded that using 10% from Hibiscus has a good effect on immunoglobulin in rats.