It is well known that, agriculture is an important industry that helped and provided the humanity with the necessary food, feed, fibre and fuel from the ancient centuries. So, a crucial role for agriculture and its sustainability should be identified. Concerning the sustainable agriculture, it means how to supply the humans with previous essential living supplies without any compromising of needs for future generations. This needs definitely the integration among the environment and its quality, economic profitability, social and economic equity as well as maintaining or conservation of the water and land resources. Moreover, farming systems should use fewer inputs and natural resources without any reducing of agricultural yields in order to reach economic profitability, the safety of the environment and social fairness. Therefore, this review will focus on the sustainability of the agriculture from a holistic overview.