THE DODDER plants are well known as holo-parasitic stem weeds and belong Cuscuta genius (family Convolvulaceae), including about 200 species distributed worldwide. Cuscuta spp. have the ability to cause a serious damage to several agricultural and horticultural crops, which estimated to be than 300 million farmers in the world, causing severe losses in the yield of many crops. The main problem of dodder plants represents in penetrating host plant tissues by the haustoria of Cuscuta and uptake everything from the host plants including nutrients, water, macromolecules (i.e., proteins and mRNAs), and even pathogens through vascular connections. As parasitic weeds, several applied materials have been used to control the Cuscuta plants like nutrients (e.g., Ca, B, K, N, and Si) and herbicides, but the nanoparticles or nanomaterials are still need concern. This is a call for submission articles including original papers, reviews, notes on the expected role of nanoparticles like nano silica on control Cuscuta plants in horticultural orchards. Is nano silica the right applied nanoparticles to control Cuscuta spp. in horticultural orchards?