After menopause, coronary heart diseases increase in females reaching the incidence of men in the same age group.
This is mostly due to the change in lipid profile to an atherogenic fonn. The aim of our study was to assess the effect of
garlic extracts in different doses on the lipid profile of surgically menopausal females. The study included forty five
females matched for age and body weight, and indicated for hysterectomy with bilateral saJpingoophorectomy. Cases
were divided into three equal groups; fifteen patients each. Group I received no treatment, Group II and III received 600
& 1200 mg garlic extracts for 3 months postoperative respectively. There was significant increase in total serum
cholesterol and LDL and a decrease in HDL in females in group 1. While in groups II & III, there was a significant
decrease of total cholesterol and LDL, with an increase in HDL. Garlic extracts in a dose of 1200 mg daily were more
effective than in the dose of 600 mg daily.