Egyptian onion is a famous economical plant rich with different primary and secondary metabolites which possess to have high biological actions such as antioxidant, antimicrobial, ant-inflammation and antiviral activities, The aim of the present research was to determine the antiradical and antioxidant effects of various individual organic and inorganic extracts obtained from unused red onion residues (red onion peels). In the present work, four extracts (Chloroform, ethyl acetate, ethanol and water) were assessed against different radical and oxidizing agents such as DPPH•, ABTS radicals' methods and potassium permanganate as a non-radical method compared with natural antioxidant standard (ascorbic acid) and silver nanoparticles of most promising extract (red onion water extract, Ag-NPs-W), in addition to analysis of active compounds of extract using Gas Chromatography–mass/mass spectrometry (GC-MS/MS). The obtained data revealed that: all antioxidant assays go parallel showing that the promising extract concentration and time of incubation are dependent and proportional to the concentration of phenolic compounds content. Water extract of red onion peels recorded the highest antioxidant activity when compared with the other three crude red onion peels extracts with 78.88 and 85.93 % against DPPH at 50 and 100 µg/ml respectively when compared with ascorbic acid as the natural standard (85.4 and 89.8 %) against DPPH at the same both concentrations, respectively. The data of antiradical activity of water extract showed the highest after 360 seconds (6 minutes) compared with antioxidant activity (30 min). From the obtained results it could be concluded that red onion peels water extract can be extensively used in providing of antioxidant, antiradical, and natural red pigments.