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198965

Punica granatum L var nana: A Hepatoprotective and Curative Agent Against CCl4 Induced Hepatotoxicity in Rats

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Biochemistry

Abstract

Since prehistoric times, medicinal plants and their extracts had been used as prolific sources of medications. Pomegranate is a symbol of life, longevity and in Aurvedic medicine; pomegranate is considered a pharmacy up to itself. Despite several previous studies centered to the phytochemistry and pharmacological actions of all Punica granatum L. components, however, to date, few reports about the variety nana, which implies that this species is yet under-investigated. Punica granatum L. var. nana is a dwarf variety of Punica granatum popularly planted as an ornamental plant in gardens. This study aims to determining the biomedical potentiality of the methanolic extract of Punica granatum L. var. nana leaves as source of botanical hepatoprotective and hepatocurative agents. The methanolic extract exhibited hepatoprotective and curative effects against CCl4 induced hepatotoxicity in rats and both effects were preventive and curative. The histopathological studies support the hepatoprotective and curative effects by restoring the normal tissue architecture. Furthermore, this extract was found to be safe by using experimental albino rats suggesting that it may be utilized as a potential source of some beneficial bioactive compounds.

DOI

10.21608/ejchem.2021.94024.4474

Keywords

Punica granatum L. var. nana, Lythraceae, CCl4, Hepatoprotective activity

Authors

First Name

Yasser

Last Name

Diab

MiddleName

M.

Affiliation

Department of Biochemistry, Faculty of Agriculture, Fayoum University,Fayoum, Egypt.

Email

ydiab@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Tammam

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Agriculture, Fayoum University,Fayoum, Egypt.

Email

mat01@fayoum.edu.eg

City

-

Orcid

0000-0001-9314-2697

First Name

Ahmed

Last Name

Emam

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Agriculture, Fayoum University,Fayoum, Egypt.

Email

dr.ahmed.moawad051@gmail.com

City

-

Orcid

-

First Name

Mamdouh

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Agriculture, Fayoum University,Fayoum, Egypt.

Email

mam03@fayoum.edu.eg

City

-

Orcid

-

First Name

Magda

Last Name

Mahmoud

MiddleName

E.

Affiliation

Department of Agricultural Chemistry, Faculty of Agriculture, Minia University, El-Minia, Egypt

Email

magda.ahmed@mu.edu.eg

City

-

Orcid

-

First Name

Wael

Last Name

Semida

MiddleName

-

Affiliation

Horticulture Department, Faculty of Agriculture, Fayoum University, Fayoum, Egypt

Email

wms00@fayoum.edu.eg

City

-

Orcid

-

First Name

Omnia

Last Name

Aly

MiddleName

-

Affiliation

National Research Center, Department of Medical Biochemistry, Dokki, Cairo, Egypt.

Email

onnyashraf@live.com

City

-

Orcid

0000-0003-2754-6073

First Name

Amr

Last Name

El-Demerdash

MiddleName

-

Affiliation

Muséum National d’Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Rue Cuvier, Paris.

Email

eldemerdash555@gmail.com

City

-

Orcid

0000-0001-6459-2955

Volume

65

Article Issue

4

Related Issue

29683

Issue Date

2022-04-01

Receive Date

2021-09-10

Publish Date

2022-04-01

Page Start

723

Page End

733

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 4_Pages 723-733.pdf

PDF . 1.1MB

Link

https://ejchem.journals.ekb.eg/article_198965.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=198965

Order

65

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023