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200353

Cardioprotective effect of melatonin on ischemic heart disease clinical course in elderly patients with insomnia

Article

Last updated: 01 Jan 2025

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-

Tags

Pharmaceutical Chemistry

Abstract

We aimed at studying the exogenous melatonin corrective effect on Ischemic heart disease (IHD) clinical features in elderly patients with sleep disorders. A total of 60 patients aged from 60 to 74 with IHD, angina pectoris functional class (FC) II and complaints of sleep disorder were examined. Patients of the 1st group (n = 30), received basic therapy: acetylsalicylic acid, atorvastatin and metoprolol succinate. A chemical melatonin analogue once a day was added to the basic treatment regimen of patients of the 2nd group (n = 30). Timely correction of melatonin pathogenetic deficiency in elderly IHD patients with insomnia by including its pharmacological analogues in the treatment regimen manifests significant improvement in the patients` clinical condition. This is evidenced by the following: a decrease in anginal attacks frequency, dynamics in Holter electrocardiographic study (ECG) monitoring indicators and somnological characteristics.

DOI

10.21608/ejchem.2021.93831.4420

Keywords

Ischemic heart disease, Melatonin, insomnia

Authors

First Name

Mikhail A.

Last Name

Osadchuk

MiddleName

-

Affiliation

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Email

-

City

-

Orcid

-

First Name

Inna N.

Last Name

Vasil`eva

MiddleName

-

Affiliation

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Email

-

City

-

Orcid

-

First Name

Nikolay P.

Last Name

Korzhenkov

MiddleName

-

Affiliation

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Email

-

City

-

Orcid

-

First Name

Ekaterina D.

Last Name

Mironova

MiddleName

-

Affiliation

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Email

-

City

-

Orcid

-

First Name

Maxim V.

Last Name

Trushin

MiddleName

-

Affiliation

Kazan Federal University, Kazan, Russia

Email

mtrushin@mail.ru

City

Kazan

Orcid

-

Volume

65

Article Issue

4

Related Issue

29683

Issue Date

2022-04-01

Receive Date

2021-09-01

Publish Date

2022-04-01

Page Start

693

Page End

700

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 4_Pages 693-700.pdf

PDF . 362.1kB

Link

https://ejchem.journals.ekb.eg/article_200353.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=200353

Order

62

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Cardioprotective effect of melatonin on ischemic heart disease clinical course in elderly patients with insomnia

Details

Type

Article

Created At

22 Jan 2023