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197961

Green Synthesis of Zinc oxide Nanocomposite Using Fusarium oxysporum and Evaluation of the Anticancer Effect on Hepatocellular Carcinoma

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Nanoparticles can be synthesized by chemical, physical and biological system methods. In this work, Superparamagnetic Iron Oxide@Silver nanoparticles (SPION@Ag NPs) were modified by zinc oxide nanoparticles (ZnO NPs). SPION@Ag core shell NPs were synthesized by the biological method using Fusarium oxysporum fungus and coated with ZnO NPs. This method is eco-friendly and low cost. Characterization techniques such as UV, FTIR, HR-TEM, HR-SEM, XRD and zeta potential were used. The most common type of liver cancer is hepatocellular carcinoma (HCC). Hepatocellular carcinoma was induced by a single dose of diethyl nitrosamine (DEN) 60 mg/Kg b.wt. and was followed after two days with carbon tetra chloride (CCl4) diluted with paraffin oil (50% v/v, 2 ml/Kg b.wt.) twice a week for one month. A histopathology examination was done after scarifying. Clear changes were shown in the comparison between the HCC group treated with ZnO@SPION@Ag nanocomposite and the positive control group. Liver function tests showed a highly significant decrease after using the nanocomposite for HCC treatment. Our study aim is to evaluate the therapeutic anticancer effect of ZnO@SPION@Ag nanocomposite on hepatocellular carcinoma in male albino rats, which was synthesized by a new method called green chemistry or green synthesis.

DOI

10.21608/ejchem.2021.91841.4361

Keywords

Hepatocellular carcinoma, Drug delivery, Zinc Oxide, Nanocomposite, Anticancer

Authors

First Name

Doaa

Last Name

Rashwan

MiddleName

Sayed

Affiliation

1 Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt 2 Faculty of Medicine, Galala University, Suez, 43511, Egypt

Email

doaasayed473@yahoo.com

City

Egypt

Orcid

0000-0002-0576-0100

First Name

may

Last Name

abd el hamed

MiddleName

mohamed

Affiliation

Spectroscopy Department, National Research Centre, Dokki, Giza, 12622, Egypt

Email

may_mohamed28@gmail.com

City

egypt

Orcid

-

First Name

Mohamed

Last Name

El-deen

MiddleName

Diaa

Affiliation

Department of Biochemistry, Genetic Engineering and Biotechnology Research Division, National Research Centre, Dokki, Giza, 12622, Egypt

Email

dr_mohameddiaa1966@yahoo.com

City

Egypt

Orcid

-

First Name

mei

Last Name

afify

MiddleName

mohamed

Affiliation

Department of Biochemistry, Genetic Engineering and Biotechnology Research Division, National Research Centre, Dokki, Giza, 12622, Egypt

Email

may.affify@yahoo.com

City

egypt

Orcid

-

First Name

mona

Last Name

mohamed

MiddleName

hassan

Affiliation

Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

mona_hassan116@yahoo.com

City

egypt

Orcid

-

First Name

abd el razik

Last Name

mohamed

MiddleName

farrag

Affiliation

Professor of Histology and Histochemistry, Pathology Department, Medical Research Division, National Research Centre, Dokki, Giza, 12622, Egypt

Email

abdelrazik232@yahoo.com

City

egypt

Orcid

-

First Name

Rana

Last Name

Nagy

MiddleName

Assem

Affiliation

Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

rana_assem@yahoo.com

City

Egypt

Orcid

0000-0003-4472-0475

First Name

Heba

Last Name

A. Elhakim

MiddleName

Kamal

Affiliation

Biochemistry, faculty of Science, Cairo university, Giza, Egypt

Email

drheba_76@yahoo.com

City

Egypt

Orcid

-

Volume

65

Article Issue

4

Related Issue

29683

Issue Date

2022-04-01

Receive Date

2021-08-22

Publish Date

2022-04-01

Page Start

197

Page End

207

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 4_Pages 197-207.pdf

PDF . 1.2MB

Link

https://ejchem.journals.ekb.eg/article_197961.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=197961

Order

20

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Green Synthesis of Zinc oxide Nanocomposite Using Fusarium oxysporum and Evaluation of the Anticancer Effect on Hepatocellular Carcinoma

Details

Type

Article

Created At

22 Jan 2023