An electrochemical approach termed cyclic voltammetry (CV) on a graphite electrode(GrE) was used to determine the antipsychotic medication Triflouprazin (TRF). Electrochemical oxidation of TRF in phosphate buffer solution at (pH=6.0) revealed a peak at (0.246) V vs. (Ag/AgCl, Sat KCl electrode). A PTH /MWCNTs / GrE composite-modified electrode was created by electropolymerized Thionin on the surface of a graphite electrode with multi-wall carbon nanotubes. The analytical curve produced. under optimal conditions was linear throughout the TRF concentration range of 0. 4999 ˟ 10-11 to521.327 ˟ 10-11 mol L-1, and the limits of detection (LOD) was 3.93˟10-17 mol L-1(S/N=3 ), The linearly anodic peak current increased in proportion to the square root of the scan rate. The goal of this study is to develop a new electrode (PTH/MWCNTs/GRE) that is more sensitive and accurate at detecting TRF.