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180666

Synthesis of 3-Dimensional Chitosan/Carboxymethyl Cellulose/ZnO Biopolymer Hybrids by Ionotropic Gelation for Application in Drug Delivery

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Polymer chemistry

Abstract

Chitosan and CMC as biopolymers and ecofriendly compounds were self-assembled to form 3-dimensional network and hybrid with ZnO nanoparticles, CS/ZnO-CMC/CaCl2 was used as a carrier for in-vitro release of 5-FU as a drug model depending on pH sensitivity emulated to the human gastrointestinal medium. The drug loading capacity and entrapment efficiency were investigated. Swelling behavior of the prepared systems by different concentrations of the raw materials and cumulative release of 5-flourouracil were studied at pH 2.1 and 7.4. Kinetic studies were applied on the drug release data using Korsmeyer-peppas as a kinetic equation model to identify the diffusion mechanism. The prepared copolymers were characterized by Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA) and scanning electronic microscopy (SEM).

DOI

10.21608/ejchem.2021.76761.3765

Keywords

ZnO NPs carboxymethyl cellulose chitosan nanocomposite self, Assembly

Authors

First Name

Marwa

Last Name

Metwally

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Mansoura University, Mansoura, ET-35516-Egypt

Email

marwam89@mans.edu.eg

City

Mansoura

Orcid

-

First Name

Rafael

Last Name

Muñoz-Espi

MiddleName

-

Affiliation

Institute of Materials Science (ICMUV) Universitat de València C/ Catedràtic José Beltrán 2 46980 Paterna, València, Spain

Email

rafael.munoz@uv.es

City

Valencia

Orcid

0000-0002-8146-2332

First Name

Ibrahim

Last Name

Youssef

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Mansoura University, Mansoura, ET-35516-Egypt

Email

dsc.i.y@hotmail.com

City

Mansoura

Orcid

-

First Name

D. s.

Last Name

Badawy

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Mansoura University, Mansoura, ET-35516-Egypt

Email

dr_doria@mans.edu.eg

City

Mansoura

Orcid

-

First Name

Magdy

Last Name

Abdelaal

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Mansoura University, 35516-Mansoura, Egypt

Email

myabdelaal@gmail.com

City

Cairo

Orcid

0000-0002-1948-6413

Volume

65

Article Issue

1

Related Issue

28750

Issue Date

2022-01-01

Receive Date

2021-05-20

Publish Date

2022-01-01

Page Start

299

Page End

307

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 1_Pages 299-307.pdf

PDF . 873.2kB

Link

https://ejchem.journals.ekb.eg/article_180666.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=180666

Order

33

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis of 3-Dimensional Chitosan/Carboxymethyl Cellulose/ZnO Biopolymer Hybrids by Ionotropic Gelation for Application in Drug Delivery

Details

Type

Article

Created At

22 Jan 2023