The present article investigates the effect of finishing wet operations on functional properties imparted to bleached and partially hydrolyzed PET fabrics by loading with TiO2, ZnO and SnO2 nanoparticles. Different trials have been carried out to clarify the effect of the sequences of finishing wet process on the properties of loaded with nanoparticles PET fabrics. Characterization of the so finished fabrics was carried out through SEM, EDX and FT-IR. EDX and FT-IR have confirmed that, interaction has actually taken place between carboxylic groups created on PET fabrics and each of the applied nanoparticles. Moreover, the obtained data revealed that, the finishing wet operation has no effect on the abovementioned interaction. The effect of finishing wet operation on the functional performances of PET fabrics was evaluated by analyzing its antimicrobial activity and ultraviolet protection properties. The antimicrobial activity was tested against B. mycoides, E. coli and C. albicans. It has been found that, loading PET fabrics with TiO2 and ZnO during or after carrying final finishing process using pad-dry-cure method paves the way for imparting outstanding antimicrobial activity even after five washing cycles. Also the obtained results revealed that, the sequence of loading the applied NPs before or during or after carrying finishing wet operation highly affect the UPF values.