MMT Modified with Cationic Carbohydrates as Deliver Carrier for Praziquentel Drug - Egyptian Knowledge Bank

1139

MMT Modified with Cationic Carbohydrates as Deliver Carrier for Praziquentel Drug

Article

Last updated: 01 Jan 2025

Subjects

Abstract

UTILIZATION of modified MMT in drug delivery is now taking a …….great attention due to the considerable efficiency and miscellaneous drug type. In this study, different types of cationic carbohydrate are used for MMT to optimize the best for loading and release. Tert- aminated starch (AmS) and chitosan (CS), bearing primary amino groups, are used for modification of MMT to evaluate the feasibility of loading and release of Praziquantel drug with applicable efficiency. The modified clay was characterized by XRD, TGA and SEM. The characterization via XRD and SEM demonstrates that the chitosan has greater exfoliated intercalation properties than the Tert- aminated starch. The loading efficiency of Praziquantel by modified MMT with AmS, and chitosan was 19.5 % and 22.1 % , respectively. Drug release was studied for CS/MMT –Praziquantel hybrid and it was found that the release was directly proportional with the pH of the medium and reached to 82% at pH 7.4 after 6 hr.

DOI

10.21608/ejchem.2012.1139

Keywords

MMT, Aminated starch, Chitosan, Drug delivery, Praziquantel and Characterization

Volume

Article Issue

Related Issue

280

Issue Date

2012-04-01

Receive Date

2012-02-21

Publish Date

2012-04-30

Page Start

143

Page End

159

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 55_Issue 2_Pages 143-159.pdf

PDF . 818.4kB

Link

https://ejchem.journals.ekb.eg/article_1139.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=1139

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Type Code

292

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle