This study was designed to assess the efficacy of biodegradable gelatin / Beta-tricalcium phosphate sponge socked in concentrated growth factors (CGF) in treating periodontal intra-bony defects, as compared with biodegradable gelatin /beta-tricalcium phosphate sponges alone.
Materials and Methods:
Twenty intra-bony defects ≥4 mm and pocket depth (PD) ≥5 mm in 20 patients were selected from the outpatient clinic of Oral Periodontology Clinic, Faculty of Dentistry, Tanta University to join in this study. Patients were randomly allocated into two groups 10 patients each. Group I was treated by surgery plus biodegradable gelatin /beta-tricalcium phosphate sponges, (control group).
Group II was treated by gelatin/beta-tricalcium phosphate sponges socked in CGF. Bleeding on probing (BOP), PD, and clinical attachment level (CAL) were measured at baseline, 3, and 6months periods. Cone beam radiographs were taken at baseline, and 6 months after surgery evaluating the area of the defect (AD) and bone density (BD).
Results: Both groups showed significant improvement in clinical parameters (P≤0.05). There were statistically significant differences in all investigated parameters between the two groups at 3 and 6 months in favor of group II, except for CAL there was no significant difference between them at 6 months. A significant decrease of DA and increase in BD at 6 months was noted for both groups with significant differences between them in favor of group II (P<0.05).
Conclusion: Using a biodegradable gelatin/β-TCP socked in CGF could enhance the outcome of periodontal regeneration, as evidenced by improved bone density and reduction in the defect area.