Staphylococcus aureus is the second leading pathogenic cause of nosocomial infections and plays an important role in the development of food poisoning and purulent, systemic and nosocomial infections. This bacterium is responsible for infections such as abscess, food poisoning, third grade burns, traumatic ulcers, surgical incisions, bed sores or atrophic ulcers. Long-term use of antibiotics has led to the emergence of multi-drug resistant strains in infectious diseases. Due to increased resistance of bacteria to chemical drugs and the few side effects of medicinal plants, medicinal plants have nowadays attracted much more attention of researchers. In this regard, studies have been done on the effectiveness of medicinal plants against infectious agents such as S. aureus and methicillin-resistant S. aureus. Therefore, in this review study, native Iranian herbs that are effective on S. aureus were reported. In this review study, search terms including Staphylococcus aureus, herbs, extracts and essential oils were used to retrieve articles indexed in databases such as the Institute for Scientific Information, PubMed, Scopus, Scientific Information Database, Magiran, and Google Scholar. Garlic, pomegranate, Anethum graveolens, coriander, eucalyptus, Lawsonia inermis, Descurainia sophia, Figworts, artemisia, thyme, etc. are some of the most important anti-staphylococcal herbs.