THIS study is designed to investigate the influence of exposure to therapeutic gamma radiation on a self adhesive resin (Vertise-Flow). Twenty freshly extracted human molars were selected and used in the study. All the sound molars were examined and confirmed free of any cracks or defects. Standardized twenty discs were prepared from the selected molars of 2mm thickness, then a hole of 3mm diameter was prepared in each disc. The twenty holes prepared were restored with Vertise-Flow according to the manufacturer's instructions. Ten discs were randomly selected and subjected to an exposure dose of gamma radiation simulating the treatment dose delivered to the cancer patients, while the remaining discs were kept as control. Each sample was tested by a compressive loading via computer controlled materials testing machine, with a load of 5 KN. The maximum failure loading was reported in N, while the shear bond strength (SBS) was calculated in MPa. It was found that the SBS of self-adhesive resins were reduced upon exposure to the therapeutic dose of gamma radiation. Yet, the difference was not statistically significant. Using simplified resin restorations as the self-adhesive composite restorations could be an efficient and easy restorative for patients receiving gamma radiotherapy.