: Weeds represent a major confronting challenge, in field-grown tuberoses, under furrow irrigation system, in the Western Region of Saudi Arabia, which hamper ameliorating tuberose cut flower yield and qualities as well as bulb production. Consequently, a Split-Split-Plot field experiment, in Complete Randomized Block Design, with four replicates, was performed, at Hada AL-Sham's Agricultural Experiment Station (Macca AL-Mokarama Area, KSA) during the 2001/02 and 2002/03 growing seasons, to resolve this problem; Irrigation frequencies (irrigation after 2, 4, 6 and 8 days) comprising the whole plots; manual hand weeding (unweeded control, weeding after 4, 8, and 12 weeks) represented the sub-plots; and Herbicidal treatments (control, Pendimethalin, glyphosate and Pendimethalin plus glyphosate) in the sub-sub-plots.  The most predominant and highly prevalent weed species were Cynodon dactylon and Cyperus rotendus.  Nevertheless, Convolvulus arvensis, Malva sylvestris, Portulaca oleracea, Amaranthus viridis, Solanum nigrum, and Amaranthus sylvestris exhibited relatively medium pervasiveness.  Low weed prevalence and associations of Anagalis arvensis, Chenopodium murale, Chenopodium glaucum, Echinochola crusgalli, Eclipla prostrata, Setaria verticillata, Cirisium arvense, Lolium multiflorum, Farsetia aegyptia, Brassica tournefortii, and Flavera trinervia were also observed. High available soil moisture and frequent irrigations every two days, increased weed population density, fresh and dry weights, water use efficiency on dry weight basis, and weed control efficiency