This experiment aimed to investigate the effect of the different irrigation water sources and spraying with seaweeds on the seedlings of two plants one is salt-sensitive (Citrus sinensis) and the other is salt-tolerant (Ziziphus mauritiana) through studying growth parameters, as well as biochemical attributes and minerals in leaves of the studied plants. Four treatments were used for irrigation water as follow: (W1)The Tap Water (control) E.c = 1.2 dS.m^-1, (W2) Shatt al-Arab river (sub river) Ec = 5.2 dS.m^-1, (W3) Shatt al-arab river (main) 6.2 dS.m^-1, (W4) The well water E.c = 8.1 dS.m^-1 with 3 levels (A1, A2, A3) of seaweed treatments prepared from (Agrosign marine) in the concentration of (0, 2, 4 ml /L), The results explained  that there is a decrease in all parameters in this study with increasing the salinity of irrigation water and this is represented in well water irrigation as compared with another water types, while the interaction withseaweeds treatments caused significant increases in the growth parameters, biochemical attributes and minerals contents. This promotion was associated with increasing the concentrations to (4 ml /L), Which gave 42.94 cm in plant height, 2.00 number of shoots, 24.61 in the number of leaves, 5.34 in stem diameter, 101.2 g in fresh weight and 19.02 g dry weight. On the other hand the interaction with seaweed extract increased significantly growth parameters, attributes biochemical and mineral content, it gave the highest value A3W1 which was 3.48 mg /g in the total chlorophyll and 73.82 mg/g in total carbohydrates, while the lowest at A1W4 which was 1.38 mg/g in the total chlorophyll and 42.92 mg / g in the total carbohydrates. The activities of the enzymes superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) have shown a marked increase when increasing the level of salinity in irrigation water as well as, the seaweeds extraction caused increasing in the content of these enzymes. The treatment (A1W4) gave the highest enzymes activities CAT, SOD, BOD which was 24.10, 21.83 and 7.93 u / g / f.w respectively.