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66050

Effect of Soybean, Virgin Coconut and Moringa oleifera Seed Oils on the Propylthiouracil Induced Hypothyroidism in Rats

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Last updated: 01 Jan 2025

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Plant pest management

Abstract

This study investigated the possible effect of soybean, virgin coconut and Moringa oleifera seed oilsfor 8 weeks on Propylthiouracil (PTU) induced hypothyroidism in rats.Thirty five male albino rats were divided into two main groups; Group (I) (7 rats) was fed only basal diet and served as a negative control group. Group (II) (28 rat) were injected with (10 mg / kg / day PTU) for 15 day to cause hypothyroidism, then divided into 4 subgroups: namely control positive group based on basal diet, and 2nd, 3rd and 4th subgroup were treated orally with dose of 5ml/kg BW oils of Soybean (SO), Virgin coconut (VCO) and M.oleifera seeds (MOO), respectively beside basal diet.The results showed that PTU exposed rats showed significant decrease (P≤0.05) in serum FT3, FT4 levels and significant increase (P≤0.05) in serum TSH levels. The orall treatement with SO, VCO and MOO was significantly increased FT4 and FT3, while decreased the level of TSH comparing with the positive control group. It was also reduced level of malondialdehyde (MDA) level, significantly, increased activity of liver antioxidant enzymes-superoxide dismutase (SOD) and improved liver functions and lipid profile compared with the positive control group. So, it could be concluded that oils of soybean, virgin coconut and M. oleifera seed oils improve the role of thyroid by raising thyroid hormones and reducing oxidative stress in patients with hypothyroidism.

DOI

10.21608/asejaiqjsae.2019.66050

Keywords

hypothyroidism, Moringa oleifera seeds, Propylthiouracil, soybean oil, virgin coconut oil, thyroid stimulating hormone

Authors

First Name

Shaimaa H.

Last Name

Negm

MiddleName

-

Affiliation

Home Economic Dept., Specific Education Faculty, Port Said University, Egypt.

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Orcid

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Volume

40

Article Issue

OCTOBER- DECEMBER

Related Issue

8896

Issue Date

2019-12-01

Receive Date

2019-11-17

Publish Date

2019-12-30

Page Start

649

Page End

659

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 40_Issue OCTOBER- DECEMBER_Pages 649-659.pdf

PDF . 460.2kB

Link

https://asejaiqjsae.journals.ekb.eg/article_66050.html

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https://asejaiqjsae.journals.ekb.eg/service?article_code=66050

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Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Effect of Soybean, Virgin Coconut and Moringa oleifera Seed Oils on the Propylthiouracil Induced Hypothyroidism in Rats

Details

Type

Article

Created At

22 Jan 2023