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64903

Adverse Outcomes of Repeated Chlorpyrifos- Ethyl and Methyl Exposure in Rats: The Ameliorating Role of N-Acetylcysteine

Article

Last updated: 01 Jan 2025

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Tags

Plant pest management

Abstract

The ameliorating effect of 150 mg/kg b.w. of N-acetylcysteine (NAC) against the oral administration of 7.88 (1/25 LD50) or 202.07 (1/10 LD50) mg/kg/day for 14 days of chlorpyrifos- ethyl (CPF-E) and chlorpyrifos-methyl (CPF-M), respectively, was investigated using neurobehavioral and biochemical markers for this toxicity. Neurobehavioral tests; open field test (OFT), hole-board test (HBT), light/dark box test (LDBT) and elevated plus maze (EPM) showed increase frequency of exploration, low level of anxiety and locomotor in rats treated with either CPE-E or CPF-M, while the co-administration of  NAC to treated rats attenuated neurobehavioral parameters. Biomarkers such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), paraoxonase (PON) and adenosine 5'-triphosphatase, (ATP-ase) showed declining in their activities, while calcium (Ca+2) levels in brain were increased. However, the administration of NAC following the intoxification of CPF-E or CPF-M attenuated the values of these biomarkers. It can be concluded that NAC can be used to ameliorate the toxicity of certain organophosphorus compounds such as CPF-E and CPF-M and considered it as a choice for the prevention and treatment of either CPF-E or CPF-M -induced toxicity.

DOI

10.21608/asejaiqjsae.2019.64903

Keywords

chlorpyrifos, rat, Neurobehavioral, biochemical, N-acetylcysteine, Attenuation

Authors

First Name

Eslam

Last Name

Ezz El-Din

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University;

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Osman

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University;

Email

-

City

-

Orcid

-

First Name

Nabila

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University;

Email

-

City

-

Orcid

-

First Name

Ayman

Last Name

El-Seedy

MiddleName

-

Affiliation

Department of Genetics, Faculty of Agriculture, Alexandria University, P.O Box 21545, Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

40

Article Issue

OCTOBER- DECEMBER

Related Issue

8896

Issue Date

2019-12-01

Receive Date

2019-11-04

Publish Date

2019-12-01

Page Start

618

Page End

628

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 40_Issue OCTOBER- DECEMBER_Pages 618-628.pdf

PDF . 556.0kB

Link

https://asejaiqjsae.journals.ekb.eg/article_64903.html

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https://asejaiqjsae.journals.ekb.eg/service?article_code=64903

Order

7

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Adverse Outcomes of Repeated Chlorpyrifos- Ethyl and Methyl Exposure in Rats: The Ameliorating Role of N-Acetylcysteine

Details

Type

Article

Created At

22 Jan 2023