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The Ameliorating Role of Geraniol Oil on Renal Toxicity Induced by Some Pesticides in Rats

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Last updated: 01 Jan 2025

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Tags

Environmental health and toxicology

Abstract

The Defensive impact of geraniol (GeoH) against renal oxidative injury and nephrotoxicity induced by beta-cyfluthrin, (β-Cyf), fipronil(FPN). and their combined effects on the male rats were investigated. Eight categories, each category of male rats were used contain six rats. Category I as control, Category 2 GeOH (100 mg/kg bwt in corn oil). Categories 3, 4 and 5 rats have presented a single daily oral dose of (FPN) fipronil (4.85 mg/kg bwt), (β-Cyf ) beta-Cyfluthrin (19 mg/kg bwt)) and their combination.  Categories 6, 7 and 8 rats have presented the same doses as Categories 3, 4 and 5 with GeOH (100 mg/kg) for 28 consecutive days, respectively. Rats which was exposed insecticides compared to control recorded significant decrease in body weight and rise in kidney weight. Treatment rats recorded significant renal function disruption by increase in uric acid and serum creatinine level. Also, insecticide-treated rats revealed renal oxidative damage was spotted in insecticide-treated rats through an increase in kidney lipid peroxidation (LPO) also, kidney appeared the decrease in antioxidant enzymes. Histopathological analysis of the kidney appeared that tubular destruction with multiple vacuolations, hyaline degeneration in glomeruli, and the thick arterial wall, and irregular glomerular lining in  treated groups (FPN, β-Cyf, FPN + β-Cyf). In conclusion, the use of Geraniol (GeOH) seemed to be useful to rats, to a great extent by alleviation and decrease the damage sustained by insecticide exposure.
 

DOI

10.21608/asejaiqjsae.2019.28701

Keywords

geraniol, Fipronil, beta-cyfluthrin, Nephrotoxicity, Oxidative Stress, histopathology

Authors

First Name

Gehan I. Kh.

Last Name

Marei

MiddleName

-

Affiliation

Department of Plant Protection, Faculty of Agriculture, Damanhour University, Damanhour 22516, Egypt.

Email

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City

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Orcid

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Volume

40

Article Issue

JANUARY- MARCH

Related Issue

4685

Issue Date

2019-01-01

Receive Date

2019-02-15

Publish Date

2019-03-30

Page Start

90

Page End

98

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 40_Issue JANUARY- MARCH_Pages 90-98.pdf

PDF . 357.3kB

Link

https://asejaiqjsae.journals.ekb.eg/article_28701.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=28701

Order

8

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

The Ameliorating Role of Geraniol Oil on Renal Toxicity Induced by Some Pesticides in Rats

Details

Type

Article

Created At

22 Jan 2023