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26639

Potential Protective Effects of Propolis against Hepatotoxicity and Nephrotoxicity Induced by Monosodium Glutamate in Rabbits

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Environmental health and toxicology

Abstract

Monosodium glutamate (MSG) is used to enhance the flavour in the preparation of food to improvement the palatability. However, it induces oxidative stress and causes many health complications. This work determines the effect of MSG on kidney and liver functions and to know the protective role of propolis in male rabbits. Twenty rabbits were divided into four equal groups. Group (1) used as control, group (2) received propolis (8mg/kg body weight), group (3) received MSG (50mg/kg bodyweight) and group (4) received propolis (8mg/kg body weight) plus MSG (50mg/kg bodyweight) in the same time as combination group. The doses was given every other day for 12 weeks. Monosodium glutamate significantly elevated the concentration of thiobarbituric acid reactive substances (TBARS) and significantly decreased the concentration of reduced glutathione (GSH) and antioxidant enzymes (Catalase(CAT), Superoxide dismutase (SOD), Glutathione S-transferase (GST), Glutathione peroxidase (GPx)) in plasma, kidney and liver. Activities of liver enzymes (lactate dehydrogenase (LDH), aspartate transaminase (AST), alkaline phosphatase (AlP), gama-glutamyl transferase (GGT), acid phosphatase (AcP) and alanine transaminase (ALT)), creatinine, glucose and urea were enhanced significantly, while globulin, albumin and total protein were reduced in plasma. Also, treatment with MSG resulted in the deterioration of the histological architecture in liver and kidney. The combination group alleviated its adverse effects on liver and kidney, and this protection might be due to the antioxidant properties of propolis. In addition, the histology of liver and kidney results were supported by the biochemical findings. From the obtained results, it could be concluded that propolis capable to mitigate the oxidative stress, hepatotoxicity and nephrotoxicity induced by MSG in male rabbits.

DOI

10.21608/asejaiqjsae.2019.26639

Keywords

Monosodium glutamate, Propolis, Hepatotoxicity, Nephrotoxicity, Oxidative Stress, Antioxidant enzymes, Histological examination, Male rabbits

Authors

First Name

Mokhtar

Last Name

Yousef

MiddleName

-

Affiliation

Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.

Email

-

City

Alexandria

Orcid

-

First Name

Doaa

Last Name

El-Nassag

MiddleName

-

Affiliation

Department of Home Economics, Faculty of Specific Education, Alexandria University, Alexandria, Egypt..

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Gasser

MiddleName

-

Affiliation

Department of Food Toxicology, Regional Center for Food and Feed, Agriculture Research Center, Alexandria, Egypt.

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Food Toxicology, Regional Center for Food and Feed, Agriculture Research Center, Alexandria, Egypt.

Email

-

City

-

Orcid

-

Volume

40

Article Issue

JANUARY- MARCH

Related Issue

4685

Issue Date

2019-01-01

Receive Date

2018-12-26

Publish Date

2019-01-01

Page Start

30

Page End

42

Print ISSN

1110-0176

Online ISSN

2536-9784

Article File

ASEJAIQJSAE_Volume 40_Issue JANUARY- MARCH_Pages 30-42.pdf

PDF . 1.1MB

Link

https://asejaiqjsae.journals.ekb.eg/article_26639.html

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https://asejaiqjsae.journals.ekb.eg/service?article_code=26639

Order

4

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023