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26436

Therapeutic Effect of Milk Thistle (Silybum Marianum L) Seeds on Carbon Tetrachloride - Induced Hepatotoxicity in Rats

Article

Last updated: 23 Dec 2024

Subjects

-

Tags

Environmental health and toxicology

Abstract

The current research aimed to investigate the therapeutic effect of milk thistle (Silybum marianum L) seeds (MTS) powder compared with hepaticum drug on carbon- tetrachloride (CCl4) caused hepatotoxicity in rats. Thirty six female albino rats weighting 140±20g were divided into 6 groups. The 1st group was fed on basal diet as the negative control group (G1), while the other five groups were injected by CCl4 (i.p). The 2nd group was the positive control group (G2). Groups from 3rd to 5th  were fed on basal diet contain different ratio of  MTS powder 1, 2 and 3 %,respectively. While, the last group (G6) was fed on basal diet contain the hepaticum drug. Liver weight, relative liver weight to the body weight (L/B %), serum liver enzymes activity, total protein, albumin, bilirubin, kidney function, serum lipid profile and histopathological examination were determined. All data were statistically analyzed and the results showed that, milk thistle seeds are rich in protein, fat and fiber. Also, its oil rich in fatty acids as linoleic acid (55.12% ), oleic acid (21.78%) and palmitic acid (8.80%). Feeding hepatotoxic rats with 3 % of MTS and drug caused a significant (P ≤0.05) increase in liver weight compared to the positive control group. While, there was no significant differences (P >0.05) between the positive control group and therapeutic groups for L/B %. On the other hand, adding 1, 2 and 3% of MTS to standard diet caused a significant decrease (P ≤0.05) in ALT and AST enzymes activities level compared to the positive control group. Also, feeding hepatotoxic rats on 1, 2 and 3% of MTS and drug caused a significant (P ≤0.05) decrease in serum urea and creatinine levels. So, by increasing the levels of adding MTS powder (2 and 3%) to standard diet caused a significant improvement in liver function and histopathological examination.
 

DOI

10.21608/asejaiqjsae.2019.26436

Keywords

Milk thistle seeds, fatty acids, hepaticum drug, Hepatotoxicity, CCl4, liver function

Authors

First Name

Dalia A.

Last Name

Zaki

MiddleName

-

Affiliation

Food Science Department (Rural Home Economics), Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Email

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City

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Orcid

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First Name

Azza S.

Last Name

Abdel-Ghany

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Email

leen_swelam@yahoo.com

City

-

Orcid

-

First Name

Ayman

Last Name

Gomaa

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Email

-

City

-

Orcid

-

Volume

40

Article Issue

JANUARY- MARCH

Related Issue

4685

Issue Date

2019-01-01

Receive Date

2018-12-27

Publish Date

2019-03-30

Page Start

19

Page End

29

Print ISSN

1110-0176

Online ISSN

2536-9784

Link

https://asejaiqjsae.journals.ekb.eg/article_26436.html

Detail API

https://asejaiqjsae.journals.ekb.eg/service?article_code=26436

Order

3

Type

Original Article

Type Code

53

Publication Type

Journal

Publication Title

Alexandria Science Exchange Journal

Publication Link

https://asejaiqjsae.journals.ekb.eg/

MainTitle

Therapeutic Effect of Milk Thistle (Silybum Marianum L) Seeds on Carbon Tetrachloride - Induced Hepatotoxicity in Rats

Details

Type

Article

Created At

22 Jan 2023